What types of precision tests are relevant for 3b

I'll help explain the relevant precision testing for Stage 3B Lymphoma, focusing on current guideline recommendations.

According to the NCCN Guidelines for Non-Hodgkin Lymphoma (2023), essential molecular and genetic testing includes:

1. Core Diagnostic Tests:

• PD-L1 expression testing
• CD20 testing
• Cell of origin (COO) testing using immunohistochemistry or gene expression profiling
• FISH testing for: • MYC rearrangements • BCL2 and BCL6 rearrangements (to identify "double-hit" or "triple-hit" lymphomas)

The Leukemia & Lymphoma Society's diagnostic guidelines also emphasize these additional important tests:

1. Biomarker Testing:

• Next-generation sequencing (NGS) panels to detect specific mutations
• Flow cytometry to determine lymphoma cell type
• IHC (immunohistochemistry) testing to identify specific proteins

According to ASCO Guidelines (2023), precision testing should be:

• Performed on initial biopsy samples when possible
• Interpreted by experienced hematopathologists
• Used to guide treatment selection, particularly for targeted therapies
• Repeated if there is disease progression or relapse

Important Note: The specific tests needed can vary based on your exact lymphoma subtype (e.g., DLBCL, follicular lymphoma, etc.). Please consult with your hematologist-oncologist to determine which tests are most appropriate for your specific situation.