Ok. I should have specified "new". New is within the last two years. ADT/ARSI has been around at least 7 years. It...
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This answer was generated by AI grounded in NCCN guidelines and published medical literature. It is not medical advice. Always consult your oncologist or care team before making treatment decisions.
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- Built by OpenCancer’s team of physician-scientists and cancer survivors.
- Last updated October 15, 2025. Informational only — not a substitute for your oncology team.
Question asked:
Ok. I should have specified "new". New is within the last two years. ADT/ARSI has been around at least 7 years. It is not "new" IMO. So, what are the "new" treatments for mHSPC?
Based on your clarification about "new" meaning treatments within the last 2 years, let me focus specifically on the newest developments according to trusted medical sources.
According to the NCCN Guidelines and clinical research centers:
- Radioligand Therapy (RLT):
- While currently FDA-approved only for mCRPC, there are active Phase 3 trials specifically for mHSPC including: • PSMAddition trial studying 177Lu-PSMA-617 • ECLIPSE trial evaluating RLT combinations with ADT/hormone therapy
- Clinical Trials: According to the NCCN Guidelines, several novel approaches are being investigated:
- New combinations of existing therapies
- Novel therapeutic targets
- Emerging treatment modalities
You are absolutely correct that ADT/ARSI combinations (like enzalutamide, apalutamide, etc.) should not be considered "new" as they have been standard options for several years.
I recommend discussing clinical trial opportunities with your healthcare team, as these may provide access to the newest emerging treatments. As noted in the NCCN Guidelines, it's important to acknowledge that truly new FDA-approved treatments specifically for mHSPC have been limited in the past two years, with most innovation happening through clinical trials.
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