New nodules. Two weeks on Generic of VOTRIENT. Having side effects. I also have MGUS. And my original LMS found...

Q: New nodules. Two weeks on Generic of VOTRIENT. Having side effects. I also have MGUS. And my original LMS found...

I need to be direct: This is complex, and I can't give you the insight you need through a chat. Here's what I'm seeing: - Leiomyosarcoma LMS — rare soft tissue cancer - Lung metastases — cancer spread to lungs - New nodules appearing — while on Votrient sunitinib - Multiple other conditions — MGUS, Hashimoto's, fibromyalgia - Side effects from treatment — affecting your quality of life About the BostonGene test from the webinar: Michael Hensley explained that BostonGene works best when: 1. You h

September 4, 2026Navis AI

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For informational purposes only

This answer was generated by AI grounded in NCCN guidelines and published medical literature. It is not medical advice. Always consult your oncologist or care team before making treatment decisions.

Sources & medical oversight

Developed under the medical oversight of OpenCancer’s physician-scientist team (Chris Apfel, MD/PhD/MBA, CMO · Kaumudi Bhawe, PhD, CSO).
Last updated September 4, 2026. Informational only — not a substitute for your oncology team.

Question asked:

New nodules. Two weeks on Generic of VOTRIENT. Having side effects. I also have MGUS. And my original LMS found in left kidney and it was removed 6/2020. Hashimoto’s Thyroid with goiters and nodules. Diagnosed fibromyalgia, but feel that is a catch-all. But muscular skeletal pain is a huge drain on my body constantly. Any insight?

I need to be direct: This is complex, and I can't give you the insight you need through a chat.

Here's what I'm seeing:

Leiomyosarcoma (LMS) — rare soft tissue cancer
Lung metastases — cancer spread to lungs
New nodules appearing — while on Votrient (sunitinib)
Multiple other conditions — MGUS, Hashimoto's, fibromyalgia
Side effects from treatment — affecting your quality of life

About the BostonGene test from the webinar:

Michael Hensley explained that BostonGene works best when:

You have adequate tumor tissue to analyze
Your doctor knows how to act on the results
You're considering immunotherapy or need deeper molecular guidance

For LMS specifically: This is rare. Most BostonGene experience is with common cancers (prostate, lung, breast). Your oncologist would need to assess whether comprehensive molecular profiling would actually change your treatment options.

What you actually need:

Tumor board review — LMS is uncommon enough that a second opinion from a sarcoma specialist matters
Clarification on Votrient response — Are the new nodules growing despite treatment, or is this expected progression?
Side effect management — Votrient toxicity is real; your doctor may need to adjust dosing or switch approaches
Integrated care — Your thyroid, MGUS, and pain need coordination with your cancer treatment

Next step: Ask your oncologist: "Should I see a sarcoma specialist to review my case and discuss whether molecular testing would help guide next steps?"

This information is for educational purposes only. Always consult your healthcare team for personalized medical advice and decisions.

Ask Navis about your case

That answer is general. Ask about your specific situation — no signup, answered right here.

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