Is there a diagnostic test to predict whether neo-adjuvant therapy would work for me

According to the NCCN Guidelines for Ovarian Cancer, there is no specific diagnostic test that can predict whether neoadjuvant chemotherapy would be effective for an individual patient with ovarian cancer.

The guidelines state: "There are no established predictive biomarkers to identify patients who are likely to respond to neoadjuvant chemotherapy." (NCCN Guidelines Version 1.2023 Ovarian Cancer, page OV-6)

Instead, the decision to use neoadjuvant chemotherapy is based on factors such as:

• Stage and extent of disease
• Ability to optimally surgically cytoreduce the cancer
• Patient's overall health and ability to tolerate surgery
• Goals of treatment (curative vs palliative intent)

The guidelines recommend that "The decision to use neoadjuvant chemotherapy should be made after consultation at a high-volume center with a gynecologic oncologist." (NCCN Guidelines Version 1.2023 Ovarian Cancer, page OV-6)

So in summary, while there is no specific predictive test, an experienced gynecologic oncologist can help assess whether neoadjuvant chemotherapy may be an appropriate option for you based on your individual case. I would encourage you to discuss this question further with your oncologist, who can provide a personalized recommendation tailored to your unique situation. Let me know if you have any other questions!