I had sbrt for 1 bone met, and ihc from it was Er50Pr0, Her2 negative. Initial ihc was Er90Pr30 adter surgery. Im...

Breast CancerOctober 15, 2025Navis AI

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For informational purposes only

This answer was generated by AI grounded in NCCN guidelines and published medical literature. It is not medical advice. Always consult your oncologist or care team before making treatment decisions.

Question asked:

I had sbrt for 1 bone met, and ihc from it was Er50Pr0, Her2 negative. Initial ihc was Er90Pr30 adter surgery. Im concerned that the Er expression is,dropped which reduced affectiveness of endicrine therapy. Suggest the approaches to unsilence Er

Adding CDK4/6 inhibitors to endocrine therapy 2. Using different classes of endocrine therapy (switching between aromatase inhibitors, fulvestrant, or tamoxifen) 3. Considering clinical trials testing novel combinations

According to ESMO Guidelines:

Epigenetic modifications can contribute to reduced ER expression
Some clinical trials are investigating drugs called "epigenetic modifiers" that might help restore ER expression
DNA methyltransferase inhibitors and histone deacetylase inhibitors are being studied for this purpose

Important recommendations:

Discuss these findings with your oncologist to determine the best treatment strategy
Consider genomic testing if not already done to identify potential targeted therapy options
Ask about clinical trials investigating treatments for reduced ER expression

Remember: While ER expression has decreased, 50% is still considered positive and endocrine therapy can still be beneficial. Your oncologist can help determine the optimal approach based on your specific situation.

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