Hello, has anyone had Enhertu immunotherapy? I had my first round last week and I still feel horrible, been in bed...

I'm sorry you're feeling so poorly—that sounds really difficult. I want to help you understand what might be happening, but this situation needs immediate attention from your care team.

Important First Step:

Please contact your oncology team TODAY if you haven't already. Being in bed since Thursday with ongoing symptoms after your first Enhertu dose warrants a clinical evaluation. They need to know:

• What specific symptoms you're experiencing (nausea, fatigue, fever, pain, etc.)
• How severe they are
• Whether anything has improved or worsened

This could be normal treatment side effects that need management, OR it could be something that requires intervention.

About Enhertu (Educational Context):

What it is: Enhertu (fam-trastuzumab deruxtecan) is an antibody-drug conjugate—a targeted therapy approved by the FDA for HER2-positive breast cancers. It combines an antibody that targets HER2 with a chemotherapy drug delivered directly to cancer cells.

Common side effects after first doses can include:

• Fatigue (very common)
• Nausea/vomiting
• Low blood counts
• Infusion reactions

However, the severity and duration vary significantly between patients, and some symptoms may indicate you need supportive care (anti-nausea medication, hydration, etc.) or dose adjustments.

What You Should Do Right Now:

1. Call your oncology clinic TODAY - don't wait for your next scheduled appointment
2. Tell them: "I've been in bed since Thursday after my first Enhertu dose and still feel horrible"
3. Ask: "Do I need to be seen? Are there medications to help manage these symptoms?"

Your care team can assess whether this is manageable at home with support or if you need additional evaluation.

This information is for educational purposes only. Always consult your healthcare team for personalized medical advice and decisions.