“Starving Cancer - beyond the Metro Map”

“Starving Cancer - Beyond the Metro Map” (Jane McLelland) [#113] Brad Power September 11, 2024 “The biggest problem in oncology is not that we haven't got the treatments, but we just don't put them together and use them in the right combinations.” – Jane McLelland “If you are stage IV, and you know that they haven't got the answer, what are you going to do?

Are you just going to sit there and die, or are you going to have a go and try and look at different ways to actually save your life?” – Jane McLelland Meeting Summary When you are diagnosed with cancer, you will probably be confused and frightened. Most newly diagnosed cancer patients are unlikely to do much research.

You probably lack the ability to figure out what is going on, much less non-standard approaches to your care. But suppose you are an exceptionally active and engaged patient. What should you do? Where could you look to get advice on lifestyle factors? You may look around for every edge you can find to enhance your immune system and general health to fight your disease.

In a diagnosis that can arrive “out of the blue”, it is important to have agency and make a difference in things you can do, such as follow a healthy diet, reduce stress, get sleep, and exercise. But what is the science that shows the potential impact of these and other lifestyle factors on your possible outcomes?

Your medical team is usually focused on testing and conventional treatment options like surgery, radiation, or chemotherapy. Your doctor may have no opinion or be opposed to potentially complementary treatments like supplements. You may be scared by the toxic effects of conventional treatment and be looking for less toxic options.

Jane McLelland is uniquely qualified to provide guidance on things you can do. After being given a terminal cancer diagnosis with only a few weeks to live, Jane dug up research, some decades old, in her quest to survive. Formerly a chartered physiotherapist, Jane had the medical background to dive into her diagnosis and treatment.

Rather than aiming to cure cancer, which in many cases is unachievable, Jane’s approach was to stop it growing. Remarkably, her approach not only stopped it from growing, but it disappeared altogether. There are now clinics following her protocol, achieving successes. Her book "How to Starve Cancer" is a new approach to the treatment of cancer.

This inspirational read is updated with a new "Metro Map", Jane’s unique and revolutionary route map to starving cancer.

Jane intertwines her remarkable life story of terminal cancer to full recovery, describing how she discovered a unique cocktail of off-label drugs (drugs usually prescribed for other conditions) and supplements that effectively starve the cancer stem cell, the cell left behind by conventional treatment.

Treatment for the stem cell is hailed as the Holy Grail, so this book plugs the missing piece into why we do not have a cure for cancer.

s (drugs usually prescribed for other conditions) and supplements that effectively starve the cancer stem cell, the cell left behind by conventional treatment. Treatment for the stem cell is hailed as the Holy Grail, so this book plugs the missing piece into why we do not have a cure for cancer.

Lead cancer researchers at top oncology centers are now using this book as a guide, and Jane has a huge following of tens of thousands on Facebook and other social media. Testimonials abound from happy and delighted recovered patients and from oncologists who use her methods.

“Starving Cancer - Beyond the Metro Map” (Jane McLelland) [#113] Why might you want to better understand how cancer metabolism can be used to treat your cancer? Cancer treatments attempt to identify something that is different about cancer cells from normal cells, then target those cells or processes to hinder or kill the cancer cells. For example, chemotherapies attack cells that grow faster.

Understanding cancer “metabolism” – how cancer cells use carbohydrates, fats, and proteins from food to get the energy they need to grow and spread – and how it is different from the metabolism of normal cells can lead to additional treatment options.

Compared to healthy cells, cancer cells use more glucose, produce less energy when making what they need to multiply and spread, and favor fermentation over breaking down glucose in the presence of oxygen. Unlike surgery, chemotherapy, or radiation, metabolic therapies don’t immediately remove or kill cancer cells.

Instead, they keep cancer cells from growing by changing or slowing the cancer metabolism. The tumor eventually may shrink and die. Researchers are looking for ways to block the unique metabolic processes of cancer cells while leaving healthy cells alone by reducing the food supply to the cancer cells and disrupting the messaging systems (“pathways”) used by cancer cells.

For example, inhibiting “glycolysis” – the process of breaking down glucose to release energy – may help stop the development of cancer cells. What can you do to address your cancer using a metabolic approach? Metabolic approaches to treating cancer are in the early stages of research. They are not part of the standard of care, but show much promise.

Cancer oncologists are not taught about the metabolic pathways beyond the “Warburg effect” (a “hallmark” of cancer cells – cancer cells preferentially break down sugar using glycolysis to produce energy, rather than using the more efficient approach of normal cells). There are multiple pathways that cancer can use to increase its nutrient uptake. Blocking those pathways can weaken the cancer.

●Your treatments must be personalized to you and your medical history, which ideally should involve multiple tests. Do research to discover the unique characteristics of your cancer and identify pathways that you might want to block with supplements and off- label drugs.

ribed for other conditions) and supplements that effectively starve the cancer stem cell, the cell left behind by conventional treatment. Treatment for the stem cell is hailed as the Holy Grail, so this book plugs the missing piece into why we do not have a cure for cancer.

Lead cancer researchers at top oncology centers are now using this book as a guide, and Jane has a huge following of tens of thousands on Facebook and other social media. Testimonials abound from happy and delighted recovered patients and from oncologists who use her methods.

“Starving Cancer - Beyond the Metro Map” (Jane McLelland) [#113] Why might you want to better understand how cancer metabolism can be used to treat your cancer? Cancer treatments attempt to identify something that is different about cancer cells from normal cells, then target those cells or processes to hinder or kill the cancer cells. For example, chemotherapies attack cells that grow faster.

Understanding cancer “metabolism” – how cancer cells use carbohydrates, fats, and proteins from food to get the energy they need to grow and spread – and how it is different from the metabolism of normal cells can lead to additional treatment options.

Compared to healthy cells, cancer cells use more glucose, produce less energy when making what they need to multiply and spread, and favor fermentation over breaking down glucose in the presence of oxygen. Unlike surgery, chemotherapy, or radiation, metabolic therapies don’t immediately remove or kill cancer cells.

Instead, they keep cancer cells from growing by changing or slowing the cancer metabolism. The tumor eventually may shrink and die. Researchers are looking for ways to block the unique metabolic processes of cancer cells while leaving healthy cells alone by reducing the food supply to the cancer cells and disrupting the messaging systems (“pathways”) used by cancer cells.

For example, inhibiting “glycolysis” – the process of breaking down glucose to release energy – may help stop the development of cancer cells. What can you do to address your cancer using a metabolic approach? Metabolic approaches to treating cancer are in the early stages of research. They are not part of the standard of care, but show much promise.

Cancer oncologists are not taught about the metabolic pathways beyond the “Warburg effect” (a “hallmark” of cancer cells – cancer cells preferentially break down sugar using glycolysis to produce energy, rather than using the more efficient approach of normal cells). There are multiple pathways that cancer can use to increase its nutrient uptake. Blocking those pathways can weaken the cancer.

●Your treatments must be personalized to you and your medical history, which ideally should involve multiple tests. Do research to discover the unique characteristics of your cancer and identify pathways that you might want to block with supplements and off- label drugs.

personalized to you and your medical history, which ideally should involve multiple tests. Do research to discover the unique characteristics of your cancer and identify pathways that you might want to block with supplements and off- label drugs. You can use generative AI tools like Perplexity, Consensus, and ChatGPT.

This metabolic approach is a molecular network approach using synergistic combinations, which means that you must be treated differently, such as your dosing. Supplements may work in one cancer, but not in others, or be complicated by other comorbidities you may have. For example, If you look at whether metformin works on its own, it generally doesn’t.

However, metformin works well in combinations in blocking particular pathways. ●Get tests to learn what you might need. For example, ○PET scans can look at your glucose, glutamine, and choline, and merge them to see which one is lit up most.

“Starving Cancer - Beyond the Metro Map” (Jane McLelland) [#113] ○A gut microbiome test can see whether you have sufficient flora to create the right environment. ●Establish your best diet. ●Determine when and how to exercise. What’s next for Jane? ●She will be working with a lab and clinic to try some cocktails for more aggressive cancers, like pancreatic cancer.

How can you learn more about Jane's unique approach to cancer? ●Read Jane’s book. ●Take Jane's online course (with discount code BRAD). ●Join Jane’s Facebook group: “Jane McLelland off-label drugs for cancer”.

The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“Starving Cancer - Beyond the Metro Map” (Jane McLelland) [#113] Meeting Notes KEYWORDS cancer, work, metformin, people, pathways, key, drugs, prostate cancer, statins, doctors, tests, bit, glutamine, block, cancer cell, cocktail, jane, point, metabolic, combination SPEAKERS Jane McLelland (84%), Brad Power (8%), Rick Davis (4%), Will LaValley (3%), Brian McCloskey (1%) SUMMARY Jane McLelland, a pioneer in metabolic approaches to cancer, discussed her metabolic map, highlighting the roles of glucose, glutamine, and fatty acids in cancer metabolism.

She emphasized the importance of diet, supplements, and off-label drugs like metformin, statins, and niclosamide. She shared her personal journey, noting that her cancer markers dropped significantly with these treatments. She also discussed the potential of RNA vaccines and the need for personalized treatments based on cancer phenotypes.

niclosamide. She shared her personal journey, noting that her cancer markers dropped significantly with these treatments. She also discussed the potential of RNA vaccines and the need for personalized treatments based on cancer phenotypes.

The discussion highlighted the challenges of accessing doctors who use off-label drugs and the importance of AI tools like Perplexity for tailored treatment plans. OUTLINE Introductions ●Jane McLelland is a former physiotherapist, stage IV cancer survivor, patient advocate, educator, and author. ●She is not a doctor but a cancer survivor. ●She has an online course.

●She has a metabolic map, which is a visual representation of the metabolic pathways in cancer cells. Cancer Progression and Metabolic Pathways ●Jane McLelland has a theory of how the hallmarks of cancer can be lined up to explain cancer progression. ●Cancer starts in the cell membrane, influenced by an abnormal microenvironment.

●Key pathways are activated by the abnormal microenvironment, including nuclear factor beta and Stat3. ●Glycolysis and oxidative phosphorylation affect the microenvironment. ●She highlights the importance of understanding these pathways to develop effective cancer treatments.

Jane's Personal Cancer Journey and Treatment Approach ●Jane McLelland shares her personal experience with cancer, including multiple recurrences and the challenges she faced with traditional treatments.

“Starving Cancer - Beyond the Metro Map” (Jane McLelland) [#113] ●She emphasizes the importance of diet, supplements, exercise, and stress management in her survival. ●She discusses the role of off-label drugs like dipyridamole, lovastatin, and metformin in her treatment. ●She explains how she managed her cancer markers through various combinations of treatments and lifestyle changes.

The Role of Off-Label Drugs and Combinatorial Therapies ●Jane McLelland discusses the potential of off-label drugs like statins, metformin, and niclosamide in cancer treatment. ●She explains the concept of metabolic flexibility and how cancer cells adapt to different treatments.

●Jane highlights the importance of combining different drugs to achieve synergistic effects and improve treatment efficacy. ●She shares examples of successful treatments using off-label drugs and the need for more clinical trials to validate these approaches.

The Importance of Metabolic Flexibility and Personalized Treatment ●Jane explains the concept of metabolic flexibility and how cancer cells adapt to different treatments. ●She emphasizes the need for personalized treatment plans based on the specific metabolic phenotype of the cancer. ●Jane discusses the role of AI tools like Perplexity and Consensus in identifying potential treatment pathways.

●She highlights the importance of understanding the genetic and metabolic features of the cancer to develop effective treatment strategies.