“Review of Services for Glioblastoma Navigation”

tion services that patients and caregivers need?

“Review of Services for Glioblastoma Navigation” (Mike Pyne) [#92] ●Allow patients and caregivers to filter options based on genetic mutations, disease stages, and location ●Provide clear, unbiased information about treatments and clinical trials ●Offer a tool incorporating AI to answer patient questions ●Facilitate connecting patients with doctors who offer relevant treatments and clinical trials.

●Trusted and neutral presentation of testing and treatment options. What is needed to deliver these navigation services?

●Develop an automated process to continuously update clinical trial listings; check which ones are still active by integrating a clinical trials API or directly contacting trial providers ●Partner with advocacy groups and patient navigators to get updated information on clinical trials and include them in the platform ecosystem ●Consider ranking clinical trials and treatment options by predicted success based on large language models, once AI is improved ●Add a filter section to allow searching by multiple mutations or locations ●Incorporate more information on ketogenic diet as a treatment option ●Consult medical professionals like pathologists to review platform content and terminology for medical accuracy ●Develop a beta testing community for review and feedback ●Develop a reliable source for education content How can you learn more about glioblastoma and navigating treatment?

●See Al Musella’s discussion on navigating brain cancer here. ●See Ari Akerstein and Brad Power on empowering patients to navigate cancer care here. ●See Samira Daswani on helping patients navigate cancer here. ●See Vanessa Liu on illuminating the path of cancer care with a chatbot here. ●See Berries on introducing an app for navigating cancer care here.

The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“Review of Services for Glioblastoma Navigation” (Mike Pyne) [#92] Meeting Notes KEYWORDS clinical trials, information, treatments, patients, questions, glioblastoma, works, metal, doctors, answers, understand, platform, people, gbm, good, website, create, wanted, filter, options SPEAKERS Mike Pyne (77%), Allen Morris (7%), Misha Mehta (6%), Al Musella (3%), John Powers (3%), Brian McCloskey (2%), Amit Gattani (2%) OUTLINE 1.

Misha's introduction. (0:00) 2.Steps of how Medoh works. (4:23) 3.Breaking down information into different categories. (9:06) 4.How do you figure out the order of the information? (15:36) 5.

(7%), Misha Mehta (6%), Al Musella (3%), John Powers (3%), Brian McCloskey (2%), Amit Gattani (2%) OUTLINE 1.Misha's introduction. (0:00) 2.Steps of how Medoh works. (4:23) 3.Breaking down information into different categories. (9:06) 4.How do you figure out the order of the information? (15:36) 5.How does bias creep into the selection process? (20:09) 6.Finding a clinical trial provider.

(24:23) 7.Yes no or unsure by clicking yes. (29:07) 8.How do you handle clinical trials for natural treatments? (35:12) 9.A quick suggestion for clinical trials. (40:48) 10.The most common type of brain tumor.

“Review of Services for Glioblastoma Navigation” (Mike Pyne) [#92] TRANSCRIPT Misha Mehta I am the mother of Neev Kolte who was diagnosed with a pediatric brain tumor called DIPG. He battled for 15 months. It gives me great pleasure to introduce Mike Pyne today. Mike is uniquely qualified to talk about the navigation challenges of glioblastoma patients and his caregivers.

When he first saw his friend's challenges upon being diagnosed with GBM (glioblastoma), he set out to develop tools that would help support people in similar situations. Medoh Health revolutionizes how GBM patients access treatments and clinical trials. Simply find the search based on genetic mutations and disease stages.

There are many apps that are currently in the market that would help cancer patients and their caregivers to navigate and automate some of these cancer journey tasks. But none that is specifically made for GBM, and this tool is specific for GBM. Medoh Health is at an early stage of design, and Mike is working on a second iteration of a prototype.

That's what he's going to be talking about with us today. Mike Pyne 1:50 Thank you very much, Misha. Thanks, everyone. My name is Mike. I'm one of the cofounders of Medoh Health, which is a digital health platform that helps glioblastoma patients search, find, and understand treatments and clinical trials that are available today.

As most people have probably experienced on this call, when you are diagnosed with cancer, time is of the essence. I noticed that one of my friends who was diagnosed with glioblastoma wanted to understand and find what treatments and clinical trials options were available to him other than what his doctor was offering him.

He said he couldn't believe how difficult it was for him to understand the information, understand what he was eligible for, and then even find the doctors that offer that treatment or clinical trial as a service. He asked me to help him navigate it because I have nearly ten years experience of working in the medical device space.

I basically did sales, marketing, product development for innovators of orthopedic treatment options. But I also created a lot of content around educating patients on the options they had available. When I tried to help him, I couldn't believe how difficult it was.

n the medical device space. I basically did sales, marketing, product development for innovators of orthopedic treatment options. But I also created a lot of content around educating patients on the options they had available. When I tried to help him, I couldn't believe how difficult it was.

I knew there were some platforms out there that you could easily just try and search the different clinical trials that are available. But the information was extremely difficult to understand because there was so much medical jargon. Then from that I even found he had so many questions about all of these treatments.

And none of them could be answered from different websites and trying to navigate the web. So what I decided to do was just create a simple platform that allows patients to search by filtering out what options they have based on their genetic mutation, where they live, and the stages of the disease, if they're newly diagnosed or a reoccurrence.

Because we didn't want to give them too many options, we wanted to be more specific. What I also wanted to do is help them understand. I just didn't want to give them a clinical trial. I didn't want to give them a treatment.

I wanted them to have their questions answered by basically incorporating an AI tool that allows them to ask questions about the treatment or clinical trial they're looking at.

“Review of Services for Glioblastoma Navigation” (Mike Pyne) [#92] offer that treatment in their local area or close by. And then the last part is their eligibility: help them understand if they're highly eligible, or not eligible at all by asking them a few simple questions about their condition about their experiences in layman's terms that they will be able to answer themselves.

And those are basically the four steps of how Medoh works. So what I would like to do is basically show you how it works. Each stage, I'm going to pause and ask for any feedback. I am open to answering any questions you guys may have, and I want to keep it as informative and engaging as possible. So I'm just going to share my screen now.

And I'm going to start with just showing you and giving you an overview of exactly how Medoh works. And in each stage, I'll pause and I'd be willing to answer any questions any of you may have. I just want to also state that we're in the early stages of the development of Medoh. So there might be a few little mistakes or it might be perfect, but that's why I wanted to do this call.

So we can get a little bit of feedback and make little improvements on areas that might not be perfect or areas that can be improved. So as you can see here, what I noticed was there's definitely a few different companies out in the market that do something similar to Medoh, but Medoh differentiates in two very different ways.

The first one is, we wanted to give patients options without them having to fill out hundreds of questions.

you can see here, what I noticed was there's definitely a few different companies out in the market that do something similar to Medoh, but Medoh differentiates in two very different ways. The first one is, we wanted to give patients options without them having to fill out hundreds of questions.

The way I thought about it is anytime someone's looking for a house, they go to Zillow to look at the different options they have first. Once they find a house, they contact a realtor and then all the work behind it actually goes on to make sure they can buy the house or rent it. I wanted to do the same thing with Medoh.

I wanted to make it as easy as possible by filtering down some of the options by giving patients treatments that they can actually learn and understand about their potential potentially eligible for. I didn't want to create any barriers to entry. The second thing is, I wanted to filter out the ones that weren't going to be applicable from the start without asking for too much information.

“Review of Services for Glioblastoma Navigation” (Mike Pyne) [#92] their condition, the variation or mutation that the patient has. As you can see, we have hundreds of different mutations that we just put in. And again, only some of these are relevant, but we want to try and include them all. The reoccurrence. Are you newly diagnosed? Or is this a reoccurrence? And then the location you are in.

The reason why we thought it was important to put the location is because we thought it'd be a lot easier just to filter down the options that are within 100 mile radius or a 200 mile radius of where you currently live. That would just give the patient less choice. And it would also just help them understand: this is what's local to me.

But if they wanted to find the options that are outside them, they can always use a filter. So all you pretty much have to do from that is enter generic pieces of information and press the search bar.

If you don't know your mutation, if you don't want to put it in a location, and you just want to try the whole of the US, you can literally remove those pieces of information and it will just give you more options across the whole of the United States for clinical trials and treatments. And then when you press search, it basically goes to the next stage. So that is the basic search function.

And I know that's really simple. But does anyone have any questions about those particular things that I just spoke about? Brian McCloskey 7:45 What if you have multiple mutations? Mike Pyne 7:53 A really good point. What we're trying to do, and what we're going to do is, on this particular part of the page, we're going to add a filter section.

And basically, that filter will allow you to edit or add more filters to it.