“Precision Medicine, AI, and Metabolic Interventions for Cancer Control

to the hormone treatment, and cells that are fully resistant, relying on alternative signals and not responding to hormone signaling or having found ways to get around your drugs. The central idea behind adaptive therapy is that this resistance comes at a cost. You're a gardener.

You keep those sensitive cells always available, so that you're always responsive to your drug, and the disease becomes a chronic illness instead of a terminal illness. This approach shows promise in mouse models and in a small trial of prostate cancer.

(For more on Bob Gatenby’s theories and his study pulsing abiraterone for prostate cancer patients, please see our notes from his two sessions - #9 and #21.) 2.Video Monitoring of Health Status To maintain their disease chronically and stably, advanced cancer patients need to monitor changes to their symptoms, pain, and disease activity to decide when they need to change their treatments.

It's wonderful if you have a tumor marker that you can monitor, such as PSA for prostate cancer patients, but many patients do not have one, and some of the biomarkers, including PSA, can be unreliable. We need better tools to monitor biomarkers frequently, and that are scalable and easy to access. There are many tests and services for monitoring patients’ health.

(For more on these services, please see our discussion with Mike Snyder, meeting #52). Current tools mostly fall into two groups: ●Cheap and scalable . For example, a patient questionnaire. The data is quite shallow, it has low predictive value, and is not very diagnostic. ●Expensive and manual . For example, MRI, CT, and PET scans.

The data can be very diagnostic, useful, and sensitive, but you don't have a scanner in your house, and you can't be using it every week. Chris Gregg and his colleagues are aiming to fill the gap in the diagnostics marketplace by creating a tool (called Storyline) that is data rich, has high value and diagnostic and predictive capabilities, but is also very cheap and massively scalable.

With Storyline, patients follow a clinical interview through a smartphone, then the interview and associated data are moved into the cloud, and it is analyzed using a variety of AI algorithms.

They can pull out over 20,000 different microfeatures, such as facial movements, facial patterns, pallor, blinking rates, and speech analysis to get a deep understanding of what people are saying, what they're articulating, and how that compares to the thousands of patients that have been through the system before. It's not just what they say, but how they say it.

Chris is also using Storyline to track his symptoms and hack his cancer, using the behavioral fingerprints of different types of pain. 3.

“Precision Medicine, AI, and Metabolic Interventions for Cancer Control" (Chris Gregg) [#53] The next problem to solve to make cancer a chronic disease is to attack the mechanisms of resistance in the cancer cells.

ing the behavioral fingerprints of different types of pain. 3.Metabolic Treatment

“Precision Medicine, AI, and Metabolic Interventions for Cancer Control" (Chris Gregg) [#53] The next problem to solve to make cancer a chronic disease is to attack the mechanisms of resistance in the cancer cells.

Building on the theory of adaptive therapy, how can you exploit or expand the cost of resistance to a treatment to make these treatments work more effectively, handicapping the resistant cells so that they can't take over? Nutrition (“food as medicine”) can attack metabolic pathways that resistant cells are using to be resistant to a treatment.

There are many diets that are proven to work – such as inflammatory signals, glucose spikes, healing the microbiome, ketogenic, starving, and other diets. The primary problem to solve is compliance. Especially if you're sick, or you don't have a lot of social support, it's very hard to comply with a diet that would actually cause a meaningful clinical effect.

Diet programs need to have palatable food, be easy to follow, and effective. Call to Action Chris is an amazing scientist and biohacker who is solving his cancer care. There are many kindred citizen scientists in our community, such as Jeff Krolick, who described his approach to supplements, including mushrooms, in this session.

You can engage with Chris by joining his free “Uncharted Health” masterclass (at www.unchartedhealth.org). It will teach you the basic principles of cancer care and give you access to the Storyline symptom trackers, a nutrition program, and his “Metabolic Switching” ebook. You can email him at chris@storylinehealth.com . By donating your health data (e.g.

, biomarkers, tumor burden, scan results) and monitoring your symptoms, you will understand your own symptoms more deeply and accurately and help train the models that can track very subtle microsymptoms and predict disease activity. And with the meal program, you will be able to test the food delivery and quality.

The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab/Prostate Cancer Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“Precision Medicine, AI, and Metabolic Interventions for Cancer Control" (Chris Gregg) [#53] Meeting Notes The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Prostate Cancer Lab, its

Interventions for Cancer Control" (Chris Gregg) [#53] Meeting Notes The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Prostate Cancer Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health. Discussion Outline 1.Introductions (0:00) 2.Adaptive therapy. (3:11) 3.Better approaches for adaptive therapy for cancer. (7:47) 4.How to use the QR code. (13:48) 5.How to help build the algorithms. (20:33) 6.

The ketogenic diet and prostate cancer. (26:32) 7.The ketogenic diet and androgen deprivation therapy. (31:00) 8.What supplements do you take to fight cancer? (36:10) 9.Integrating EMR data into the storyline. (43:34) 10.What’s involved in growing your own mushrooms?

(52:14) SUMMARY KEYWORDS patients, psilocybin, symptoms, cells, nk cell, storyline, diet, cancer, mushrooms, problem, treatment, idea, androgen deprivation therapy, moffitt cancer center, moffitt, data, test, metabolic, sensitive SPEAKERS Chris Gregg (48%), Jeff Krolick (30%), Brian McCloskey (13%), Russ Hollyer (6%), Rick Stanton (2%) Brian McCloskey We are very honored today to have Chris Gregg with us.

Chris is a scientist working in neurogenetics and behavioral artificial intelligence to make precision medicine available to everyone. He's currently a tenured associate professor in the Department of Neurobiology and Anatomy and Human Genetics at the University of Utah School of Medicine, and he is the co- founder and CFO of Storyline Health. Chris is also a stage four cancer patient.

He has a rare form of male breast cancer with estrogen receptor and progesterone receptor plus HER2. He has known for three and a half years that his life expectancy was three years. Four years ago he put together a program on extinction strategy using control of metabolic pathways, inflammatory signals, glucose spikes, etc., in a way to starve the cancer.

He also leads a masterclass called Uncharted Health, which pulls together knowledge that is available today to more effectively control progression based on ecological and evolutionary principles.

“Precision Medicine, AI, and Metabolic Interventions for Cancer Control" (Chris Gregg) [#53] I'm very curious to see where Chris is going to lead us today. I see some synergy with some sessions that we've had with Bob Gatenby out of the Moffitt Cancer Center, who is an evolutionary biologist, and also runs their radiation oncology department. Chris Gregg 3:11 I've been looking forward to this talk for quite a while to be honest. One of the things that I hope