“Patient Navigators Your Guide through the Clinical Trial Journey”

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] Brad Power July 3, 2024 “The goal of the patient navigator is to reduce the complexity surrounding clinical trials, guiding patients seamlessly from their initial intake call through to enrollment.

We're here to help patients understand their treatment options beyond standard of care, and address their concerns about participating in clinical trials.” – Madeleine Carrier, PharmD “We're trying to find and help the patients that are not at an academic center or with a physician that is not doing trials every day.

” – Dennis Akkaya “From attending conferences and establishing partnerships with patient advocacy groups, we're seeing the landscape change. This is a really important time. That's why we enjoy doing webinars and educating people on the fact that aside from your physician, there are resources, such as ours, where you can see your other options.

” – Madeleine Carrier, PharmD Meeting Summary Patients and caregivers often perceive clinical trials as risky and unpredictable compared to standard treatment. Many fear being treated like “research subjects” in an experiment, without knowing that there should be no compromise on the standard of care in a clinical trial environment.

Additionally, clinical trials often provide comprehensive testing at no cost to the patient, offering greater insight into treatment effects. Madeleine Carrier, a patient navigator at myTomorrows, and Dennis Akkaya, Chief Commercial Officer at myTomorrows, are uniquely qualified to lead a discussion about how patients and caregivers can navigate clinical trials.

myTomorrows is a company which helps patients discover and access treatments, bridging the gap between those searching for all possible options and the BioPharma companies who develop them. Why should you consider a clinical trial? ●Extra options: Clinical trials are often used when you have exhausted all standard of care treatments.

However, clinical trials should be considered upfront and throughout the whole process of treatment selection, as one of the options that are available and should be prioritized. ●Access: By choosing a clinical trial, you may be trying the next therapy in the standard of care much sooner than you would have otherwise.

In addition to getting access to medications that are additional options, you can also access options in timing and drug combinations. What are the challenges that you can face when trying to access clinical trials? ●Awareness: Not knowing that there are clinical trial options.

●Data Availability: Assembling and sharing medical records , essential for selecting treatments and qualifying for trials. They are often scattered across various healthcare providers.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] ●Testing Requirements : Enrollment in cli

bility: Assembling and sharing medical records , essential for selecting treatments and qualifying for trials. They are often scattered across various healthcare providers.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] ●Testing Requirements : Enrollment in clinical trials frequently requires specific tests, such as genomic sequencing, which you may not have had.

●Complex Trial Matching : Not being aware of your options beyond standard care - clinical trials are not seen as standard considerations when developing treatment plans. The abundance of clinical trial options can make selection a daunting process. Factors to consider include eligibility criteria and the number of required visits.

●Travel Considerations : Your ability and willingness to travel to trial sites can vary, impacting your ability to participate.

●Enrollment Process : After selecting a clinical trial, you must communicate with multiple entities to complete enrollment, adding to the complexity; uncertainty about who to contact and the information required; you may get a slow response or no response from the clinical trial site.

●Managing Expectations : You should understand the probabilities of expected outcomes; watch out for a false hope that a clinical trial will deliver an exceptional outcome. How can patient navigators assist you in your cancer treatment journey?

●Address any barriers you face in understanding your options ●Explain the clinical trials process and how to get enrolled ●Match you with a clinical trial ●Prescreen you to see whether you will qualify for a clinical trial ●Enroll you in a clinical trial, including helping you collect medical records and sending them to the research site ●Describe the different roles of your medical team members and discuss how relationships with them work, improve your communication with your medical team What can you do to learn more about patient navigation services?

●See myTomorrows’ service related to clinical trials and the role of patient navigators. ●Read or watch our discussion with Selin Kurnaz of Massive Bio about finding your best clinical trial. How can you ensure that you understand your clinical trial options and improve your access to them? ●Ask your provider about prioritizing clinical trials.

Consider clinical trials not as your last option, but as your first option. ●Share with other patients and caregivers the advantages of a more proactive consideration of clinical trials. ●See our discussion with Kevin Freiert of Salem Oaks on educating patients and caregivers about clinical trials .

cords , essential for selecting treatments and qualifying for trials. They are often scattered across various healthcare providers.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] ●Testing Requirements : Enrollment in clinical trials frequently requires specific tests, such as genomic sequencing, which you may not have had.

●Complex Trial Matching : Not being aware of your options beyond standard care - clinical trials are not seen as standard considerations when developing treatment plans. The abundance of clinical trial options can make selection a daunting process. Factors to consider include eligibility criteria and the number of required visits.

●Travel Considerations : Your ability and willingness to travel to trial sites can vary, impacting your ability to participate.

●Enrollment Process : After selecting a clinical trial, you must communicate with multiple entities to complete enrollment, adding to the complexity; uncertainty about who to contact and the information required; you may get a slow response or no response from the clinical trial site.

●Managing Expectations : You should understand the probabilities of expected outcomes; watch out for a false hope that a clinical trial will deliver an exceptional outcome. How can patient navigators assist you in your cancer treatment journey?

●Address any barriers you face in understanding your options ●Explain the clinical trials process and how to get enrolled ●Match you with a clinical trial ●Prescreen you to see whether you will qualify for a clinical trial ●Enroll you in a clinical trial, including helping you collect medical records and sending them to the research site ●Describe the different roles of your medical team members and discuss how relationships with them work, improve your communication with your medical team What can you do to learn more about patient navigation services?

●See myTomorrows’ service related to clinical trials and the role of patient navigators. ●Read or watch our discussion with Selin Kurnaz of Massive Bio about finding your best clinical trial. How can you ensure that you understand your clinical trial options and improve your access to them? ●Ask your provider about prioritizing clinical trials.

Consider clinical trials not as your last option, but as your first option. ●Share with other patients and caregivers the advantages of a more proactive consideration of clinical trials. ●See our discussion with Kevin Freiert of Salem Oaks on educating patients and caregivers about clinical trials .

The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

g discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action. You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104]

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] Meeting Notes KEYWORDS patients, clinical trials, trials, patient navigators, physicians, options, site, question, Madeleine, dennis, referrals, journey, companies, report, travel, brad, screening, institution, study, expanded SPEAKERS Dennis Akkaya (64%), Madeleine Carrier (25%), Brad Power (6%), David Plunkett (2%), Rob Weker (2%), Roger Royse (1%) QUESTIONS SUBMITTED VIA CHAT Allen Morris, David Plunkett, Erika Hanson Brown, Ryan Moon, Robert Weker, Kuldip Ahluwalia, Cheryl Middleton, Clifford Reid, Nusantara SUMMARY Patient navigators can play a crucial role in guiding patients through their clinical trial journey, providing personalized support, understanding the patient's journey, and addressing concerns.

They can help patients in matching them with clinical trials, raising awareness about trial options, and improving the patient experience. Ideally there should be a dedicated point of contact, medical training, language support, and early education to build trust and facilitate the referral process.

Patients should be educated about clinical trial options earlier in the treatment process to make informed decisions. OUTLINE Introductions. ●Dennis Akkaya and Madeleine Carrier introduced themselves and discussed patient navigation and clinical trial access at myTomorrows. Patient navigators' role in helping patients find and access relevant trials.

●Patients can schedule a call with a patient navigator to learn about clinical trials tailored to their medical profile. ●Patient navigators help foster shared decision-making between patients and physicians, potentially leading to enrollment in clinical trials. ●Patient navigators provide dedicated support from initial contact, answering questions and addressing concerns.

●Patient navigators explain clinical trial concepts, address eligibility criteria, and build trust throughout the journey.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] A case example of patient navigation for a cancer clinical trial, emphasizing personalized support and trust. ●A patient was aware of a specific clinical trial for diffuse midline glioma and reached out for support in understanding the enrollment process. ●Madeleine Carrier prov

ligibility criteria, and build trust throughout the journey.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] A case example of patient navigation for a cancer clinical trial, emphasizing personalized support and trust. ●A patient was aware of a specific clinical trial for diffuse midline glioma and reached out for support in understanding the enrollment process.

●Madeleine Carrier provided pre-screening and addressed concerns about the study design and placebo arm, facilitating the patient's referral to the site. ●Patient navigators assist cancer patients throughout the treatment journey, providing personalized support and connecting them with relevant resources.

Patient navigation for clinical trials, including intake process, platform, and funding models. ●A systematic approach ensures seamless transition from exploration to potential engagement with clinical trial sites. ●Pharmaceutical companies prefer to work with patient navigators, as they provide a more comprehensive view of trial options for patients.

●A clinical trials navigation service helps patients by providing information on all their options, without promoting any particular company. Genetic testing and clinical trials for cancer patients, with insights on patient knowledge and awareness. ●Patients often lack knowledge on genetic testing for eligibility criteria in clinical trials.

●Patients at community hospitals may lack knowledge of clinical trial options, while those at academic institutions have more awareness but may need help enrolling. Barriers to clinical trial participation and ways to overcome them. ●Patients are often unaware of clinical trial options beyond standard care. ●Physicians are stretched thin, unable to keep up with the latest research.

●Patients receive personalized guidance through patient navigators, reducing confusion and uncertainty. ●Navigation services provide a streamlined process for sites, with organized referrals and compliant documentation. Clinical trial enrollment, patient eligibility, and informed decision-making.

●Madeleine Carrier discusses challenges in ensuring patients qualify for clinical trials, including distance and resource allocation. ●She emphasizes the importance of considering clinical trials upfront and throughout the treatment process. Clinical trials, patient advocacy, and access to treatments.

●Speakers discuss the importance of educating patients about clinical trials as an option for treatment. ●Patient shares personal experience of benefiting from enrolling in a clinical trial earlier in the treatment process.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] ●Madeleine Carrier mentions cross-border referrals for clinical trials, acknowledging complexities such as visas, work permits, and consent.

s Akkaya) [#104] A case example of patient navigation for a cancer clinical trial, emphasizing personalized support and trust. ●A patient was aware of a specific clinical trial for diffuse midline glioma and reached out for support in understanding the enrollment process.

●Madeleine Carrier provided pre-screening and addressed concerns about the study design and placebo arm, facilitating the patient's referral to the site. ●Patient navigators assist cancer patients throughout the treatment journey, providing personalized support and connecting them with relevant resources.

Patient navigation for clinical trials, including intake process, platform, and funding models. ●A systematic approach ensures seamless transition from exploration to potential engagement with clinical trial sites. ●Pharmaceutical companies prefer to work with patient navigators, as they provide a more comprehensive view of trial options for patients.

●A clinical trials navigation service helps patients by providing information on all their options, without promoting any particular company. Genetic testing and clinical trials for cancer patients, with insights on patient knowledge and awareness. ●Patients often lack knowledge on genetic testing for eligibility criteria in clinical trials.

●Patients at community hospitals may lack knowledge of clinical trial options, while those at academic institutions have more awareness but may need help enrolling. Barriers to clinical trial participation and ways to overcome them. ●Patients are often unaware of clinical trial options beyond standard care. ●Physicians are stretched thin, unable to keep up with the latest research.

●Patients receive personalized guidance through patient navigators, reducing confusion and uncertainty. ●Navigation services provide a streamlined process for sites, with organized referrals and compliant documentation. Clinical trial enrollment, patient eligibility, and informed decision-making.

●Madeleine Carrier discusses challenges in ensuring patients qualify for clinical trials, including distance and resource allocation. ●She emphasizes the importance of considering clinical trials upfront and throughout the treatment process. Clinical trials, patient advocacy, and access to treatments.

●Speakers discuss the importance of educating patients about clinical trials as an option for treatment. ●Patient shares personal experience of benefiting from enrolling in a clinical trial earlier in the treatment process.

“Patient Navigators: Your Guide through the Clinical Trial Journey” (Madeleine Carrier, PharmD, and Dennis Akkaya) [#104] ●Madeleine Carrier mentions cross-border referrals for clinical trials, acknowledging complexities such as visas, work permits, and consent. ●Roger Royse asks about trials outside the US, citing the UK's recent RNA vaccine trial launch and the need for coordination and information sharing. Clinical trial navigation and personalized search reports for patients. ●Pa