“Novel Testing to Guide Personalized Cancer Treatment”

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] Chad Magnussen, Dr. Lauren Cohen, Dr. Miven Donato, Panagiotis Apostolou, and Brad Power June 7, 2023 “The current treatment model, even when "personalized," is personalized to the cancer, not the unique expression of the cancer within each individual patient's physiology.” – Dr.

Lauren Cohen “Cancer patients need clear information about what treatment options will be effective for them.” - Dr. Lauren Cohen Meeting Summary Advanced cancer patients want personalized treatment, which depends on testing to gather data about each patient's unique profile.

The current treatment model, even when "personalized," is personalized to the cancer, not the unique expression of the cancer within each individual patient's physiology.

The one-size-fits-all model in current cancer care has low success rates, typically less than 30%, leaving patients to guess or gamble with their treatment selection, without knowing if they fall within that 30% success group or the 70% failure group before making that decision. Cancer patients need clear information about what treatment options will be effective for them.

RGCC testing provides clear information about the quantity and activity level of the cancer cells, genetic expressions showing what drives and inhibits the cancer cell growth, and chemosensitivity testing on chemotherapeutic agents and natural substances to determine which are effective treatment options. Dr.

Lauren Cohen, DC, Managing Director of RGCC International - North America and members of the RGCC Clinical & Scientific Team, Dr. Miven Donato, and Panagiotis Apostolou described the tests they employ to custom tailor cancer treatment uniquely to each patient. Using more and better tests can save time, money, health, and provide peace of mind.

●Not wasting time or money on treatments that won't be effective, leaving resources available for treatments that are. ●Many chemotherapeutic treatments are very hard on the body. If you are going to pay that high a physical price, you want to know the "price" is worth it.

●Being armed with personalized information about what treatment options are right for you, gives you the peace of mind knowing you are not guessing and hoping for the best, but making sound decisions with actionable information.

With the Onconomics Plus test you get information about your circulating tumor cells, you get genetic and physiological expressions such as growth factors, resistance factors, angiogenesis factors, cell cycle regulation, metastasis, drug metabolism and targets, and even radiotherapy and hyperthermia sensitivity.

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] so that when you are making choices about care options, you know exactly which chemotherapy agents and

chemo sensitivity testing on 117 chemotherapeutic agents and targeted therapies, along with more than 53 natural substances,

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] so that when you are making choices about care options, you know exactly which chemotherapy agents and natural substances are going to work for you.

The Onconomics Plus test results consist of 24 pages, this is the test that provides all the information you need to determine what is effective therapy for whatever cancer that is tested. And so the therapeutic options that one will obtain from this test covers a broad number of different therapeutic approaches.

In order to receive RGCC testing, it is essential that you get connected with an RGCC practitioner. RGCC only works with RGCC registered practitioners. So even if you have a naturopath or primary care physician, they can't just order a test unless they are registered RGCC practitioners. Chad Magnussen, one of the patients in the Prostate Cancer Lab community, got tests from RGCC.

He described his experience with RGCC, and RGCC used his test report to illustrate their services, and answer questions such as: Q: How do you position RGCC's services? A: RGCC is more than a lab. RGCC has an entire testing system that provides personalized information that guides you through the entire cancer journey.

The system contains tests for baselines, cancer cell activity and prognosis, genetic and physiological expressions creating individualized profiles used to create customized treatment protocols for each patient, chemosensitivity testing of chemotherapeutic agents and natural substances, immune status, and monitoring at the microscopic level during treatment for protocol efficacy and early detection of recurrence when traditional medical monitoring is not sensitive enough to detect.

Although there are other labs that do individual pieces of what we do, we are the only lab that provides this testing in a comprehensive and cohesive system. Q: Do you primarily work with blood as input? A: RGCC specializes in liquid biopsy using blood samples that can be collected at any time during the cancer journey.

We can also use fresh tissue samples, but they must be fresh, collected at the time of the excision or biopsy, not paraffin embedded. And of course, this is often a one-time option since surgery is not routinely done every 3 months or so to gather a new sample, and any material left over is embedded in paraffin which preserves the tissue but not the CTCs.

In addition, biopsy/excision samples are like a time capsule. Cancer cells mutate over time, especially after treatment is done. Using a tissue sample collected 6 months or more prior, no longer matches the cancer cells currently being expressed in the patient's body. Using fresh blood samples keeps the information current.

tissue sample collected 6 months or more prior, no longer matches the cancer cells currently being expressed in the patient's body. Using fresh blood samples keeps the information current.

The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Prostate Cancer Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61]

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] Meeting Notes The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Prostate Cancer Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health. Discussion Outline 1.Disclaimers. (0:00) 2.Introduction to RGCC. (2:41) 3.Personalization and partnership in cancer care. (8:53) 4.Therapeutic options for prostate cancer. (17:11) 5.Hormone-driven cancer. (24:15) 6.

How to order a test. (33:18) 7.The remission and recurrence prevention program. (39:52) 8.Which tests do you use for RGCC testing? (43:12) 9.Access and interpretation of the test. (50:17) 10.The missing information about gene expression.

(54:46) SUMMARY KEYWORDS test, cancer, gcc, patient, agents, work, resistance, genes, practitioner, lab, ctc, question, natural substances, treatment, chad, information, cells, ngs, cancer cells, determine SPEAKERS Dr. Lauren Cohen (40%), Dr.

Miven Donato (40%), Brad Power (7%), Chad Magnussen (6%), Jonathan Starr (4%), Panagiotis Apostolou (4%), Robert Gurmankin (<1%) Meeting Notes Brad Power 0:03 This is the Prostate Cancer Lab/Cancer Patient Lab. We're pleased to have representatives from RGCC with us who are a testing and diagnostic service, and we'll be learning about the services they can offer to patients.

Chad, can you please do a quick introduction of RGCC and the background for why we're having our session today? Chad Magnussen 1:18 The reason I started with RGCC is because I’m seeing a naturopath functional doctor, and I was talking to him about the book How to Starve Cancer and how I was interested in blocking certain pathways.

And he said to me that the best way to do that would be to get an RGCC report and actually have some actionable ways to block certain pathways.

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ctor, and I was talking to him about the book How to Starve Cancer and how I was interested in blocking certain pathways. And he said to me that the best way to do that would be to get an RGCC report and actually have some actionable ways to block certain pathways. You may be throwing some

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] supplements out, something that really isn't doing you any benefit. So his suggestion was to get this report. And so we did that, and I have developed a supplement protocol from this report that I have quite a bit of confidence in.

The other part is I'd already completed chemotherapy when I got this report, but there's some interesting information that I think they'll touch on that would be very helpful to someone newly diagnosed. So that's how I started. And basically we'll just turn it over to I believe Lauren to present. Dr. Lauren Cohen 2:41 We just want to say that we are very excited to be here.

And Chad, thank you so much for introducing us to this community. This is an amazing patient-oriented community. And what you're going to find is RGCC is very patient focused, and a very different experience with a lab than you may have had before. Something we specialize in is helping patients find personalized information so that they can make informed personalized decisions about their cancer.

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] This presentation has a lot of ground to cover.

The overview itself could normally take anywhere between, say 30 to 45 minutes, but we're going to do a very brief overview because we're doing something very special today, which is taking one of our tests, our most comprehensive tests, the Onconomics Plus test, and we're going to do an interpretation demonstration.

So you can see how the information that you get on your test can be interpreted and utilized to make a very personalized protocol for you as an individual person. And then of course, we're going to leave time for Q & A.

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] I'm Dr. Lauren Cohen. I am the managing director of RGCC International which is the US-based branch of RGCC International. We have Dr. Miven Donato, who is an active practicing clinician, he's also an RGCC-accredited clinician, and he is also one of the members of our clinical support and training team.

And he is going to be doing our interpretation portion of the presentation today. And lastly, we have Panagiotis Apostolou. He's our lab manager in Greece, and he is also a molecular biologist.

He won't be presenting today, but he is here so that he can answer as many questions as can be answered, because we do know that you are a community of citizen scientists, and we want to make sure that we have enough staff here to be able to answer any questions that may arise.

“Novel Testing to Guide Personalized Cancer Treatment” (RGCC) [#61] Our founder Dr. I