“How AI Is Shifting the Dynamics of Your Next Doctor Visit”

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] Brad Power November 20, 2024 “Most people will begin to either rapidly or slowly embrace these technologies, depending on their personality, and it will change that interaction in every aspect. Patients will come into their visits a lot more prepared.

This will be preparation that goes a step further than the typical Google search, because it will be relevant to their specific case and backed up by real data, not by everything available on the internet that can sometimes be not only misleading, but even border on dangerous.” – Ezra Cohen, MD “Fasten your seat belts because things are changing so fast.

It is amazing, and, personally, it is fun to be a part of it.” – Ezra Cohen, MD Meeting Summary How will AI change the relationships between patients, caregivers, and doctors as each is empowered with more information and understanding? New AI (artificial intelligence) tools are revolutionizing every aspect of your life, including your healthcare.

With AI, your medical information will be easy to access and share. You will increasingly be able to ask questions and gain insights about your personal medical issues in everyday language and get answers using the best of the world's medical research in an understandable and digestible format. Physicians will also be better prepared for guiding patients with specific, up-to-date information.

Ezra Cohen, MD, the Chief Medical Officer of Oncology at Tempus AI, is uniquely qualified on the impact of AI on relationships between doctors, patients, and caregivers. He is a leading medical oncologist and cancer researcher who brings a unique combination of extensive clinical and research experience.

He was most recently the Chief of the Division of Hematology- Oncology as well as the Associate Director of Clinical Science at UC San Diego (UCSD) Moores Cancer Center. Dr. Cohen also led the Precision Immunotherapy Clinic and co-directed the San Diego Center for Precision Immunotherapy at UCSD. Before UCSD, Dr.

Cohen spent 15 years at the University of Chicago, where he was the co-director of the Head and Neck Cancer Program as well as Hematology/Oncology Fellowship Program Director. He joined Tempus AI, a provider of genomic testing and other services, in 2023. Dr. Cohen helped guide Kasey Altman, a young cancer patient with a rare cancer, through her pursuit of immunotherapy.

He contributed to the hackathon we ran for her. Why do you need to understand the coming disruption of the traditional relationships of doctors, patients, and caregivers by AI? AI-enabled software agents will be used to support you in seeking better outcomes through personalized care.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121]

ing better outcomes through personalized care. Cancer care often involves making complex medical decisions within a challenging environment: a balkanized medical system of many specialists, information overload

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] and obsolescence, limited time with doctors, and siloed data. New AI tools can enable you to more actively participate in your treatment decisions. For example, consider receiving a complex scan report in a patient portal. Today you may be confused trying to interpret it, adding to your anxiety (“scanxiety”).

However, a personalized generative AI agent can translate the scan report into language you can understand, and even contextualize it within your personal health history and clinical evidence/guidelines. By providing an understandable version of the report and the clinical context of your test results, you can engage more fully in decision-making with your medical team.

How will patients and caregivers be impacted by AI? Until now, the healthcare industrial complex has owned all medical data. But the data is the patients’ data, and patients will have access to it. A next generation of apps will allow patients to control their healthcare journey in a much more meaningful way.

Olivia, a Tempus app prototype, is an example of a vision for a patient-facing, AI-enabled app that would empower you to access and organize your medical records, manage your health, and receive personalized insights. It’s in beta testing at Tempus.

Here are examples of prompts to illustrate the capabilities that could be available directly to you: ●Connect to my provider(s) to upload and consolidate all of my records in one place ●Help me prepare for my upcoming appointment ●Help me understand my treatment options ●Is there a clinical trial I should consider? ●What does a “complete response” mean? ●How can I improve my lifestyle?

Patients will come into their visits a lot more prepared. Patients will be armed with tools to report their symptoms in real time and track them over time, e.g., wearable or interactive tracking. Armed with these insights, patients and caregivers will still face barriers of access to tests and treatments that they identify. AI may be able to help with this problem.

How will healthcare providers be impacted by AI? ●Visit preparation: The physician will be armed with the latest data and information, specific to that patient, e.g., test recommendations, treatment recommendations, referral recommendations, drug-drug interactions. ●Notifications: Continuous notifications will come from patients and caregivers, e.g.

, from monitoring devices, and the medical team will have to respond to them. AI can triage the notifications and route them to different members of the medical team. ●Treatment access : AI will help doctors in writing the letters that enable patients to access non-standard treatments.

“How AI Is Shifting the Dynamics of

, and the medical team will have to respond to them. AI can triage the notifications and route them to different members of the medical team. ●Treatment access : AI will help doctors in writing the letters that enable patients to access non-standard treatments.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] How will relationships between doctors, patients, and caregivers change with AI? ●No change for many : There will be a large segment of the patient population that will want to continue their interactions with their provider as it is now.

●Better prepared: Patients, caregivers, and providers will come into any meeting better prepared. Decision support will be massively upgraded. ●Capturing interactions : The patient-doctor visit is going to be tracked and recorded in a much more concise way. An AI-enabled tool will capture all the relevant information and create a note for the provider, patient, and caregiver. What’s next?

●Personalization: We will be able to accurately predict individual patient outcomes based on real data from hundreds of millions of data points, rather than what a population will do. Payers, providers, and patients will see this predictive accuracy and embrace personalized solutions over population guidelines because these will generate the best patient outcomes.

●Big data: Integrating all health data, including consumer data, will provide a comprehensive view of a patient's health. ●Tests: The increasing number of tests and the depth of testing, e.g., whole genome sequencing, will uncover more information than current methods.

●Breakthroughs: Breakdowns and breakthroughs will occur as the pace of innovation from AI in healthcare explodes, while healthcare stakeholders struggle to adopt what is available. ●Fewer specialists and fewer physicians : AI may handle more routine tasks, reducing the need for as many specialists. In a decade, there will be a need for fewer physicians.

We don't have enough physicians right now, and it will help that we won't need as many physicians in total. How can you learn more?

●Sign up to get access to Olivia from Tempus when it becomes available around June 2025 ●Engage with service providers like Tempus to provide patient and caregiver perspectives The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] Meeting Notes KEYWORDS AI in healthcare, patient empowerment, Tempus database, clini

c situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] Meeting Notes KEYWORDS AI in healthcare, patient empowerment, Tempus database, clinical trial matching, patient-provider relationship, AI tools, molecular data, patient records, lifestyle management, rare cancers, whole genome sequencing, patient engagement, medical records, decision support, future of AI SPEAKERS Ezra Cohen (75%), Brad Power (8%), Brian McCloskey (5%), Cindy Ness (4%), Kay Coleman (3%), Alane Watkins (2%), Eric Dishman (2%), Olivia video (2%) CHAT CONTRIBUTORS Allen Morris, Alexander Lalov, Erin Carron, Rick Davis, Roger Royse, Brian McCloskey, Richard Anders, Robb Owen, Chad Magnussen, Eric Dishman, Chris Apfel, Kay Coleman SUMMARY Ezra Cohen discussed how AI is transforming the relationship between doctors and patients, emphasizing Tempus's role in leveraging multimodal data to improve patient care.

Tempus's database now exceeds 200 petabytes, with 7 million de-identified records, surpassing TCGA by 50 times. Key tools like NEXUS, Pixel, and Lens aid in care pathway intelligence, clinical trial matching, and patient-specific insights. Tempus Link enhances clinical trial accrual by matching patient eligibility with trial criteria.

Olivia, a patient-facing app for medical record access and personalized insights, was introduced. Future plans include whole genome sequencing and integrating consumer data. OUTLINE Introductions and Overview ●Ezra Cohen has expertise in immunotherapies and is the Chief Medical Officer at Tempus.

●The presentation provides an overview of Tempus's AI initiatives and aims to stimulate discussion and explore the future of AI in healthcare, focusing on how AI is shifting the dynamics of doctor visits and the potential for disruption in patient care. Tempus's Services ●Tempus's multimodal database includes molecular, clinical, and imaging data from over 2500 institutions.

●Tempus uses these data to develop AI tools that help in drug development and provide insights for treatment selection and care pathways.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] ●The company has a significant database, with over 200 petabytes of data and 7 million de-identified records. ●Tempus's tools, like NEXT and Pixel, help in identifying care gaps and tracking the size of nodules, respectively.

●Tempus Link is a tool that helps match patients to clinical trials based on their eligibility criteria. ●The tool has been successful in improving clinical trial accrual by notifying providers about eligible patients. ●The Lens database allows for sophisticated queries, such as identifying patients with specific mutations and their treatment outcomes.

by notifying providers about eligible patients. ●The Lens database allows for sophisticated queries, such as identifying patients with specific mutations and their treatment outcomes. ●A video showcased Olivia, a patient-facing app that empowers patients to access and organize their medical records and receive personalized insights.

Workforce Readiness and AI Integration ●Eric Dishman asked about the training and integration of AI tools in oncology practices and the long-term implications for the workforce. ●Ezra explains that Tempus works closely with healthcare systems to ensure smooth implementation and addresses the need for ongoing training.

●He envisions a future where AI may handle more routine tasks, reducing the need for as many specialists. ●Brian McCloskey raises concerns about access to drugs and the role of AI in expediting this process. Addressing Physician Concerns and Lifestyle Management ●Cindy Ness asked about the role of AI in patient engagement and the inclusion of lifestyle management data in tools like Olivia.

●Ezra acknowledged the importance of lifestyle management and said that while it is not included in the current version of Olivia, it is a future consideration. ●Alane Watkins asked about the applicability of AI tools to rare cancers and the involvement of smaller institutions in Tempus's trials.

●Ezra explained that Tempus is working with various institutions and emphasizes the importance of being comfortable with one's provider. Patient-Centric Questions and Future Directions ●Kay Coleman asked if Olivia can be applied to non-cancer patients and expressed concern about missed medical issues.

●Ezra confirms that Olivia can be used for any patient and acknowledges the need for more comprehensive tools in the future. ●Brian McCloskey inquires about the consistency of molecular data interpretation across different providers. ●Ezra explains that while there may be differences in interpretation, the analytic perspective has improved significantly over the years.

Final Thoughts and Future Innovations ●Brad Power asked Ezra about Tempus's future plans and the inclusion of consumer data in their analysis.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] ●Ezra mentioned Tempus's investment in whole genome sequencing and the potential for uncovering more information than current methods. ●Ezra emphasized the importance of integrating all health data, including consumer data, to provide a comprehensive view of a patient's health. ●He encouraged everyone to fasten their seat belts as AI in healthcare is rapidly evolving.

“How AI Is Shifting the Dynamics of Your Next Doctor Visit” (Ezra Cohen, MD) [#121] TRANSCRIPT Brad Power This is the Cancer Patient Lab. We're very honored to have Ezra Cohen with us today. Ezra is someone we've known for a long time. He was very helpful in the Kasey Altman hackathon some years ago. He's been an expert in immunotherapies, personalize