“Exercise as a Countermeasure to Hormone Deprivation Therapy Side Effects and for Bone and Mental Health”

mobility impairment during neurotoxic chemotherapy and several NCI supplements to integrate digital technology as a tool for continuous passive monitoring of symptoms, mobility and quality of life in aging cancer patients. What are the complex health challenges that advanced cancer patients face? People with cancer are often older and face problems from aging, as well as other conditions besides cancer. Cancer treatment side effects can either accelerate functional declines or add

“Exercise as a Countermeasure to Hormone Deprivation Therapy Side Effects and for Bone and Mental Health” (Kerri Winters-Stone) [#48] new problems that accelerate functional decline. It changes body composition, causes extreme fatigue, and can result in slowness, weakness, and instability. Hormone therapy adversely affects bone health and strength.

The condition of "frailty" leads to falls, combined with bone weakness, that can cause fractures, and those end up creating significant morbidity and mortality. Other side effects from cancer treatments include cardiovascular disease, diabetes, and loss of independence. What are the benefits of exercise? Dr.

Winters-Stones’ research projects have established that an exercise program using bone loading is able to completely stop bone loss in the spine for men on androgen deprivation therapy.

The broader benefits of exercise, such as resistance training, include the ability to do more activities without any assistance, cardiovascular and metabolism improvements, and reductions in circulating insulin levels and body fat. What exercise program should you do?

You should work towards aerobic exercise three to five days a week, 30 to 60 minutes at a time; resistance training two to three days a week; and flexibility, stretching, and mobility every day. This isn't any different than the public health guidelines.

But each one of those have different benefits and an ideal program would contain those different modalities, and these are the doses that are effective. How should cancer patients with bone metastases exercise? If you do exercises without weights and your form is correct, the risk is relatively low. As you start to increase weights, and if you do things incorrectly, the risk is going to increase.

You should avoid highly dynamic, rapid loading kind of exercises, twisting exercises, hyperflexion hyperextension, or any extreme loading on the bone. You should be careful of exercises where the weights are away from the midline of your body. Any advice on supplements? ●Calcium: For women who are hormone deficient, e.g.

, postmenopausal, the recommendation is about 1500 milligrams of calcium a day. For men, it’s 1500 milligrams a day and you should break up your doses throughout the day, with no more than about 500 milligram per dose, e.g., at breakfast, lunch and dinner. Calcium citrate tends to be the most absorbable followed by calcium carbonate.

calcium a day. For men, it’s 1500 milligrams a day and you should break up your doses throughout the day, with no more than about 500 milligram per dose, e.g., at breakfast, lunch and dinner. Calcium citrate tends to be the most absorbable followed by calcium carbonate. Oyster shell calcium is not as good as Citric Cal or some other supplements that are on the market.

●Vitamin D: It depends on where you live. For those in Oregon, who don't get vitamin D in the wintertime, you might benefit from a supplement. What do we need to do in the future? Our goal is to make the patient’s quality of life as high as possible, for as long as possible.

We know that exercise has the potential to control disease progression and to improve treatment side effects, but it is not yet part of standard care. Patients should have a warm handoff after treatment to an exercise program.

“Exercise as a Countermeasure to Hormone Deprivation Therapy Side Effects and for Bone and Mental Health” (Kerri Winters-Stone) [#48] The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Cancer Patient Lab/Prostate Cancer Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

“Exercise as a Countermeasure to Hormone Deprivation Therapy Side Effects and for Bone and Mental Health” (Kerri Winters-Stone) [#48] Meeting Notes The information and opinions expressed on this website or platform, or during discussions and presentations (both verbal and written) are not intended as health care recommendations or medical advice by Prostate Cancer Lab, its principals, presenters, participants, or representatives for any medical treatment, product, or course of action.

You should always consult a doctor about your specific situation before pursuing any health care program, treatment, product or other course of action that might affect your health.

SUMMARY KEYWORDS exercise, adt, bone, trial, people, kerri, program, cancer, called, whole body vibration, men, bone loss, frailty, study, test, prostate cancer, improve, work, funded, guidelines SPEAKERS Amit Gattani, Mike Yancey, Jeff Krolick, Kevin Fordney, Brad Power, Brian McCloskey, Russ Hollyer, Rick Stanton, Kerri Winters Brad Power We're honored to have Kerri Winters-Stone with us today.

I met Kerri through Cathy Skinner, who previously led a discussion with us on exercises for cancer patients. Kerri Winters 00:16 Cathy Skinner connected us through Katie Schmitz (a professor and leader in exercise for cancer patients)..

o have Kerri Winters-Stone with us today. I met Kerri through Cathy Skinner, who previously led a discussion with us on exercises for cancer patients. Kerri Winters 00:16 Cathy Skinner connected us through Katie Schmitz (a professor and leader in exercise for cancer patients)..

Kerri is not only an expert, but she is also involved in clinical trials, which means there's an opportunity to potentially participate in some of the things that she's got going. It's a "twofer." Kerri is at OHSU.

“Exercise as a Countermeasure to Hormone Deprivation Therapy Side Effects and for Bone and Mental Health” (Kerri Winters-Stone) [#48] Kerri Winters 02:11 Thanks for the invitation. I was excited to talk to all of you and to learn about your group and what you're aiming to do, and how I can potentially be helpful. Brad said prepare a couple of slides.

Well, you say that to an academic, it's like I'll take my slide deck of 45 down to 10. I will walk you through who I am and my research program. I would love to get a little bit more in depth, but I know that this isn't quite the forum for that quite yet. As Brad mentioned, a lot of my work is focused more broadly on exercise oncology.

But I'd say probably 50% of the work that I've done since moving into this field has been in prostate cancer and specifically on using exercise as a countermeasure to ADT (androgen deprivation therapy). Hopefully, I'll be able to provide you with some helpful information today.

“Exercise as a Countermeasure to Hormone Deprivation Therapy Side Effects and for Bone and Mental Health” (Kerri Winters-Stone) [#48] I’ll start by giving you a little bit of an idea of who I am and how I got into exercise oncology. I started out at UC Davis. I heard someone was from the SAC area. I started out in California, and I am a human performance major.

This is a field that may be unfamiliar to some people. But it's the more sophisticated version of physical education.

It was really where we moved the field toward using exercise to study how to make people stronger and faster and more competitive and harnessing those adaptations that happen from exercise training and using it to actually help either prevent disease in the first place, or to help manage disease when somebody has it either by controlling disease or managing the side effects.

I did my PhD at Oregon State University down in Corvallis in human performance. At that time, I moved from working with athletes to working with women to use exercise as a way to prevent osteoporosis.