What options are there for stage 4 melanoma? What tests should I get? Are there any relevant clinical trials

For stage 4 melanoma, there are several treatment options that may be recommended based on guidelines from groups like the National Comprehensive Cancer Network (NCCN) and American Society of Clinical Oncology (ASCO). I'll summarize some key points from their resources:

Treatment Options (MELANOMA - About melanoma pp. 37-38):

• Targeted therapy - Drugs that target specific gene mutations like BRAF
• Immunotherapy - Medications that help the immune system fight cancer
• Chemotherapy - Anti-cancer drugs, sometimes used with immunotherapy
• Radiation therapy - Using high-energy rays to kill cancer cells
• Surgery - To remove tumors if possible
• Clinical trials - Studying new drug combinations or approaches

Recommended Testing (MELANOMA - Testing pp. 22-26):

• Biopsy to confirm melanoma diagnosis and staging
• Testing for BRAF, NRAS and KIT gene mutations to guide targeted therapy options
• Imaging tests like CT, PET, and MRI scans to look for spread
• Blood tests to check general health

Clinical Trials: There are many clinical trials going on for stage 4 melanoma exploring new drug combinations, immunotherapies, and approaches. The National Cancer Institute website (cancer.gov) has a clinical trial finder tool you can use to search for melanoma trials. Discussing options with your oncologist is important.

It's critical to have your case reviewed by a multidisciplinary team of melanoma experts to develop the best treatment plan for your individual situation based on testing results, cancer characteristics, and your preferences. I'd recommend getting a second opinion at a major cancer center if possible as well. Let me know if you need any clarification or have additional questions!