What genetic tests are recommended for me

Genetic Tests Recommended for Prostate Cancer

Based on the NCCN (National Comprehensive Cancer Network) Guidelines, there are two main types of genetic testing recommended for people with prostate cancer:

1. Germline Testing (Hereditary Gene Testing)

This test looks for inherited mutations passed down from your parents that may have increased your risk of developing prostate cancer. It uses a sample of your blood, saliva, or urine.

You should consider germline testing if you have:

• Family history of prostate, breast, ovarian, colorectal, or certain other cancers
• High-risk or very-high-risk prostate cancer (regardless of family history)
• Ashkenazi Jewish ancestry
• Known family mutations in genes like BRCA1, BRCA2, ATM, or CHEK2
• Any other type of cancer in addition to prostate cancer

Key genes tested include:

According to NCCN Guidelines, germline testing typically looks for mutations in:

• BRCA1 and BRCA2 (also linked to breast, ovarian, pancreatic, and melanoma)
• ATM and CHEK2
• MSH2, MSH6, MLH1, and PMS2 (also linked to colorectal and uterine cancers)
• PALB2 and others

Why this matters: Finding an inherited mutation can help guide your treatment options and alert family members who may also carry the mutation.

2. Molecular Biomarker Testing (Tumor Testing)

This test analyzes the cancer tissue itself from your biopsy to understand how aggressive your cancer might be and how likely it is to spread.

What it does:

• Helps determine if you have lower-risk or higher-risk prostate cancer
• Can help you decide whether to pursue active surveillance or immediate treatment
• May identify specific mutations that respond to targeted therapies

According to the NCCN Guidelines, biomarker testing "can be considered for those with localized, regional, or metastatic prostate cancer."

Next Steps

I recommend discussing both types of testing with your healthcare team. The NCCN Guidelines specifically recommend working with a genetic counselor—a specialist trained in genetic diseases who can:

• Help you understand your family history
• Explain which tests are most appropriate for you
• Interpret your results
• Discuss implications for family members

Important: These tests provide valuable information, but they work best when interpreted by your medical team in the context of your complete medical picture.

Would you like to know more about what these test results might mean for your treatment options?