What biomarker tests should I ask my doctor about

LymphomaOctober 15, 2025Navis AI

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For informational purposes only

This answer was generated by AI grounded in NCCN guidelines and published medical literature. It is not medical advice. Always consult your oncologist or care team before making treatment decisions.

Based on the NCCN Guidelines for Patients, here are the key biomarker tests you should discuss with your doctor for Lymphoma:

For Follicular Lymphoma (FL): According to the NCCN Guidelines for FL (2024), essential biomarker testing includes:

Immunophenotyping tests:

Immunohistochemistry (IHC) panel testing for markers including:
CD20, CD3, CD5, CD10, BCL2, BCL6, CD21/CD23
Flow cytometry testing for:
Kappa/lambda, CD19, CD20, CD5, CD23, CD10

Genetic testing:

BCL2 and BCL6 rearrangements
Testing for chromosome translocations
Fluorescence in situ hybridization (FISH) studies

For Diffuse Large B-Cell Lymphoma (DLBCL): According to the NCCN Guidelines for DLBCL (2025), key biomarker testing includes:

Essential genetic tests:

MYC, BCL2, and BCL6 gene rearrangements
FISH testing for these rearrangements if MYC is positive
Karyotype testing

Immunophenotyping:

IHC panel including CD3, CD20, CD10, BCL2, BCL6, IRF4/MUM1, and MYC
Flow cytometry markers including CD3, CD5, CD19, CD10, CD20, CD45

The guidelines emphasize that these tests should be interpreted by expert pathologists and are crucial for accurate diagnosis and treatment planning. Always discuss the full panel of appropriate tests with your healthcare team, as individual needs may vary.

Sources:

NCCN Guidelines for Patients: Follicular Lymphoma, 2024
NCCN Guidelines for Patients: Diffuse Large B-Cell Lymphomas, 2025

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