What are the diagnostic tests available based on nccn

Based on the patient's clinical summary, I'll outline the relevant diagnostic testing recommendations for Glioblastoma Multiforme (GBM) according to authoritative sources:

According to the NCCN Clinical Practice Guidelines for Central Nervous System Cancers, the standard diagnostic workup should include:

1. Imaging Studies:

• MRI with and without contrast (which the patient has received, as evidenced by the documentation of enhancing lesions)
• Advanced imaging techniques such as: • MR Spectroscopy • Perfusion imaging • Diffusion imaging • PET imaging (the patient has already undergone C11-methionine PET imaging, as noted in the summary)

1. Molecular Testing (NCCN Category 1 recommendation):

• IDH mutation status
• MGMT promoter methylation status
• 1p/19q codeletion testing
• ATRX mutation
• TERT promoter mutation

The National Cancer Institute (NCI) additionally recommends:

• Regular neurological examinations
• Cognitive function assessments
• Performance status evaluation (which is documented as 0 in this case)

Important note from the clinical summary:

• The document states "Molecular testing details not specified in available records" - this suggests a potential gap in documented testing that should be addressed according to current guidelines.

ASCO Guidelines also emphasize:

• The importance of regular surveillance imaging to monitor treatment response and disease progression
• The need for ongoing seizure assessment and management (particularly relevant given the patient's recent seizure history)

Recommendation based on guidelines: Since molecular testing details are not specified in the records, it would be important to verify whether comprehensive molecular testing has been performed according to current NCCN guidelines, as this could impact treatment decisions and clinical trial eligibility.

Always consult with healthcare providers for specific testing recommendations, as individual cases may require modified approaches based on clinical circumstances.