NED Hello, Just wondering if anyone here who took or is taking tagrisso was ever NED after progression? Waiting for...

Understanding NED Status and Tagrisso (Osimertinib)

I can hear the anxiety in your message—waiting for scan results is genuinely stressful. Let me provide some educational context that might help while you wait.

What NED Means

NED = No Evidence of Disease. This means imaging and other tests show no detectable cancer, though it doesn't necessarily mean cancer is completely gone at a cellular level.

Tagrisso and NED Achievement

The encouraging news: Yes, patients taking Tagrisso (osimertinib) do achieve NED status, including some after prior progression.

Here's the clinical context:

For EGFR-mutant lung cancer specifically:

• According to NCCN Guidelines, Tagrisso is a third-generation EGFR tyrosine kinase inhibitor (TKI) used for patients with EGFR mutations
• In clinical trials, patients treated with Tagrisso have achieved complete responses and NED status
• Some patients who progressed on earlier EGFR inhibitors (like erlotinib or gefitinib) have responded to Tagrisso because it targets resistant mutations that develop over time

Important context: Response rates and NED achievement vary based on:

• Specific EGFR mutation type
• Whether there's prior treatment history
• Individual patient factors
• Presence of other genetic changes (like TP53 mutations)

What to Expect

The American Cancer Society notes that response to targeted therapies can take several weeks to months to fully appear on imaging, so timing matters too.

Right Now

Rather than searching for others' outcomes (which can fuel anxiety without being relevant to your husband's specific situation), I'd suggest:

When you get those results, ask his oncologist:

1. What does the scan show compared to the previous one?
2. If there's response, what's the timeline for potential NED status?
3. What factors will they monitor going forward?
4. What's the plan if the cancer doesn't respond as hoped?

The waiting is the hardest part. Sending you both patience and hope for good news.

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This information is for educational purposes only. Always consult your healthcare team for personalized medical advice and decisions.