Brca2 and atm genetic mutations. should i consider cisplatin for chemo

Based on the provided NCCN guidelines sources, I can provide guidance regarding BRCA2 and ATM mutations and treatment considerations:

According to the guidelines:

1. From Source 1: BRCA mutations can affect how well some treatments work. BRCA1 and BRCA2 mutations increase risk of multiple cancers including breast, ovarian, prostate, colorectal, pancreatic and melanoma skin cancers.

2. From Source 2: ATM mutations help repair damaged DNA and kill damaged cells. ATM mutations increase risk of breast and bladder cancers and melanoma.

However, the provided guideline excerpts do not contain specific recommendations about cisplatin chemotherapy for patients with BRCA2 and ATM mutations. This would be an important treatment decision that requires consultation with your oncology team.

The guidelines consistently emphasize:

1. Treatment decisions should be individualized based on multiple factors beyond just genetic mutations

2. You should discuss all treatment options with your multidisciplinary care team who can take into account your specific situation

3. Genetic testing results "may be used to guide treatment planning" but are just one of many factors to consider

I would recommend discussing cisplatin and all chemotherapy options with your oncologist who can evaluate your complete clinical picture and provide evidence-based recommendations specific to your case.