About this document "ctDNA MRD assay (Signatera™)": How much does ctDNA MRD assay (Signatera™) typically cost

October 15, 2025Navis AI

For informational purposes only

This answer was generated by AI grounded in NCCN guidelines and published medical literature. It is not medical advice. Always consult your oncologist or care team before making treatment decisions.

Based on the document content, the ctDNA MRD assay (Signatera™) costs $1000+. However, it's important to note two key points from the document:

  1. Insurance Coverage: The test is currently listed as "No (investigational)" for insurance coverage

  2. Clinical Context: According to the document, this test is currently for "Stage II-III post-op (clinical trial use)"

For context on testing costs and coverage, I should note that:

According to NCCN Guidelines for Colorectal Cancer (current version), while circulating tumor DNA (ctDNA) testing is an emerging technology for monitoring disease, it is still considered investigational in many contexts.

The American Society of Clinical Oncology (ASCO) guidelines also indicate that while ctDNA testing shows promise for monitoring colorectal cancer, more evidence is needed before it becomes standard of care, which affects both insurance coverage and out-of-pocket costs for patients.

I would recommend:

  1. Discussing with your healthcare provider about the necessity and timing of this test
  2. Checking with your specific insurance provider about any potential coverage
  3. Asking about any available financial assistance programs or clinical trial opportunities that might cover testing costs

This is general information.

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