About this document "BRAF V600E testing": What is this

Let me explain this diagnostic test document based on the provided information, citing authoritative sources:

According to the NCCN 2024 Guidelines, BRAF V600E testing is a molecular diagnostic test specifically used for colorectal cancer patients, particularly those with metastatic disease. The test serves two key purposes:

1. Prognostic Value: The test identifies the BRAF V600E mutation, which according to the American Society of Clinical Oncology (ASCO) guidelines, is associated with a poor prognosis in colorectal cancer patients.

2. Treatment Planning: As noted in the document and supported by NCCN Guidelines, this test helps identify patients who might benefit from targeted therapy, especially in RAS wild-type cases.

Key practical details from the document:

• Cost: Approximately $300
• Results waiting time: 7-10 days
• Insurance coverage: Yes
• Testing is particularly recommended for metastatic colorectal cancer patients

The National Cancer Institute (NCI) recognizes BRAF testing as a crucial molecular marker in colorectal cancer that helps guide treatment decisions. This test is considered a standard part of molecular profiling for metastatic colorectal cancer patients.

Always remember that while this information is important, any testing decisions should be made in consultation with your healthcare team.